Development strategies and research progress of SARS-CoV-2 neutralizing antibody

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) has evolved into a pandemic, which has imposed a burden on the global economy and public health, thus effective response measures are urgently needed. Antibodies have a good historic documented in the prevention and treatment of emerging infectious diseases. At present, hundreds of development projects for SARS-CoV-2 neutralizing antibodies around the world are ongoing by using different strategies, with some in clinical trials. This article reviews the current development strategies and research progress of SARS-CoV-2 neutralizing antibodies in the fields of target selection, antibody screening techinqne, functional evaluation and possible challenges.